General Information

  • ID:  hor001831
  • Uniprot ID:  Q69GG1
  • Protein name:  Pea-FMRFa-1
  • Gene name:  NA
  • Organism:  Periplaneta americana (American cockroach) (Blatta americana)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Periplaneta (genus), Blattinae (subfamily), Blattidae (family), Blattoidea (superfamily), Blattodea (order), Dictyoptera (superorder), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  AEEQNQPPPV
  • Length:  10
  • Propeptide:  MGVGIIIAMHALFFFMYHIASSDVLDGTNTIDNVAALDISEDEDDCEPESSITSLPLKRAEEQNQPPPVRRRCSNRNFVRLGRGHDFDQDDVNSSGEKDESLVRIGRGGRSNDNFIRFGRGGKNDNFIRFGRGGKQDNFIRFGRDRSDNFIRFGRGKTDNFIRFGRGRSDNFIRFGRGKSDNFIRFGRARPDNFIRFGRGKQDFIRFGRGNSNFVRFGRDDSSNVETFDTEEEATTDSTLRVGRGGKSGSNFIRFGRARPSSNFIRLGRRDEEVTQREERGRPSNNFVRFGRQTEDDDKFVRLSRSGNSNELRRGKLTDRNFIRLGRSGPSYDEKEQENEDGNSVRLGRSENPSNSRNFIRLGKRALDQNLLVDEHLMRFGRDVEQIENTPVASSGEPSRSDTDNKTKENYQQSRSKRSISFSEEDSSEDSSDYPVMIPNSAYDDVKIPSPSVEDSQIPFRYYSPLSSGIPNYILGPELSVLPPLSNESKRGRGDGHNRNYIRLG
  • Signal peptide:  MGVGIIIAMHALFFFMYHIASS
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Excitatory effects of antenna–heart;reduce the spike frequency of dorsal‐unpaired median neurons and reduce the intracellular calcium concentration
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q69GG1-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001831_AF2.pdbhor001831_ESM.pdb

Physical Information

Mass: 126888 Formula: C47H73N13O18
Absent amino acids: CDFGHIKLMRSTWY Common amino acids: P
pI: 3.61 Basic residues: 0
Polar residues: 1 Hydrophobic residues: 2
Hydrophobicity: -163 Boman Index: -2549
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 39
Instability Index: 13036 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  15355317
  • Title:  Unique accumulation of neuropeptides in an insect: FMRFamide-related peptides in the cockroach, Periplaneta americana